Javascript required
Skip to content Skip to sidebar Skip to footer
Home / What Does Keto Diet Do to Cholesterol Levels

What Does Keto Diet Do to Cholesterol Levels

Long-term effects of a ketogenic diet in obese patients

Affiliations

  • PMID: 19641727
  • PMCID: PMC2716748

Free PMC article

Long-term effects of a ketogenic diet in obese patients

Hussein M Dashti  et al. Exp Clin Cardiol. Fall 2004 .

Free PMC article

Abstract

Background: Although various studies have examined the short-term effects of a ketogenic diet in reducing weight in obese patients, its long-term effects on various physical and biochemical parameters are not known.

Objective: To determine the effects of a 24-week ketogenic diet (consisting of 30 g carbohydrate, 1 g/kg body weight protein, 20% saturated fat, and 80% polyunsaturated and monounsaturated fat) in obese patients.

Patients and methods: In the present study, 83 obese patients (39 men and 44 women) with a body mass index greater than 35 kg/m(2), and high glucose and cholesterol levels were selected. The body weight, body mass index, total cholesterol, low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, triglycerides, fasting blood sugar, urea and creatinine levels were determined before and after the administration of the ketogenic diet. Changes in these parameters were monitored after eight, 16 and 24 weeks of treatment.

Results: The weight and body mass index of the patients decreased significantly (P<0.0001). The level of total cholesterol decreased from week 1 to week 24. HDL cholesterol levels significantly increased, whereas LDL cholesterol levels significantly decreased after treatment. The level of triglycerides decreased significantly following 24 weeks of treatment. The level of blood glucose significantly decreased. The changes in the level of urea and creatinine were not statistically significant.

Conclusions: The present study shows the beneficial effects of a long-term ketogenic diet. It significantly reduced the body weight and body mass index of the patients. Furthermore, it decreased the level of triglycerides, LDL cholesterol and blood glucose, and increased the level of HDL cholesterol. Administering a ketogenic diet for a relatively longer period of time did not produce any significant side effects in the patients. Therefore, the present study confirms that it is safe to use a ketogenic diet for a longer period of time than previously demonstrated.

Keywords: Diet; Ketosis; Obesity.

Figures

Figure 1)
Figure 1)

Reduction in body weight at eight, 16 and 24 weeks following the administration of the ketogenic diet in obese patients. The weights are expressed as mean ± SEM

Figure 2)
Figure 2)

Decrease in body mass index at eight, 16 and 24 weeks during the administration of a ketogenic diet in obese patients. The values are expressed as mean ± SEM

Figure 3)
Figure 3)

Decreased levels of total cholesterol (expressed as mean ± SEM) in obese patients at eight, 16 and 24 weeks during the administration of a ketogenic diet

Figure 4)
Figure 4)

Changes in the level of high density lipoprotein (HDL) cholesterol in obese patients during treatment with a ketogenic diet for a period of 24 weeks. Data are expressed as mean ± SEM

Figure 5)
Figure 5)

Changes in the level of low density lipoprotein (LDL) cholesterol during treatment with a ketogenic diet in obese patients at eight, 16 and 24 weeks. The values are expressed as mean ± SEM

Figure 6)
Figure 6)

Changes in the level of triglycerides in obese patients during treatment with a ketogenic diet over a period of 24 weeks. The values are expressed as mean ± SEM

Figure 7)
Figure 7)

Decreased levels of blood glucose (expressed as mean ± SEM) in obese patients at eight, 16 and 24 weeks during the administration of a ketogenic diet

Figure 8)
Figure 8)

Changes in the level of urea in obese patients during a 24-week ketogenic diet. The level of urea is expressed as mean ± SEM

Figure 9)
Figure 9)

Changes in the level of creatinine in obese patients during a 24-week ketogenic diet. Values are expressed as mean ± SEM

Similar articles

  • Long term effects of ketogenic diet in obese subjects with high cholesterol level.

    Dashti HM, Al-Zaid NS, Mathew TC, Al-Mousawi M, Talib H, Asfar SK, Behbahani AI. Dashti HM, et al. Mol Cell Biochem. 2006 Jun;286(1-2):1-9. doi: 10.1007/s11010-005-9001-x. Epub 2006 Apr 21. Mol Cell Biochem. 2006. PMID: 16652223 Clinical Trial.

  • Beneficial effects of ketogenic diet in obese diabetic subjects.

    Dashti HM, Mathew TC, Khadada M, Al-Mousawi M, Talib H, Asfar SK, Behbahani AI, Al-Zaid NS. Dashti HM, et al. Mol Cell Biochem. 2007 Aug;302(1-2):249-56. doi: 10.1007/s11010-007-9448-z. Epub 2007 Apr 20. Mol Cell Biochem. 2007. PMID: 17447017 Clinical Trial.

  • Effect of low-calorie versus low-carbohydrate ketogenic diet in type 2 diabetes.

    Hussain TA, Mathew TC, Dashti AA, Asfar S, Al-Zaid N, Dashti HM. Hussain TA, et al. Nutrition. 2012 Oct;28(10):1016-21. doi: 10.1016/j.nut.2012.01.016. Epub 2012 Jun 5. Nutrition. 2012. PMID: 22673594 Clinical Trial.

  • Effects of Combined Exercise and Low Carbohydrate Ketogenic Diet Interventions on Waist Circumference and Triglycerides in Overweight and Obese Individuals: A Systematic Review and Meta-Analysis.

    Lee HS, Lee J. Lee HS, et al. Int J Environ Res Public Health. 2021 Jan 19;18(2):828. doi: 10.3390/ijerph18020828. Int J Environ Res Public Health. 2021. PMID: 33478022 Free PMC article. Review.

  • Influences of Ketogenic Diet on Body Fat Percentage, Respiratory Exchange Rate, and Total Cholesterol in Athletes: A Systematic Review and Meta-Analysis.

    Lee HS, Lee J. Lee HS, et al. Int J Environ Res Public Health. 2021 Mar 12;18(6):2912. doi: 10.3390/ijerph18062912. Int J Environ Res Public Health. 2021. PMID: 33809153 Free PMC article. Review.

Cited by 33 articles

  • Effect of a Ketogenic Diet on the Nutritional Parameters of Obese Patients: A Systematic Review and Meta-Analysis.

    López-Espinoza MÁ, Chacón-Moscoso S, Sanduvete-Chaves S, Ortega-Maureira MJ, Barrientos-Bravo T. López-Espinoza MÁ, et al. Nutrients. 2021 Aug 25;13(9):2946. doi: 10.3390/nu13092946. Nutrients. 2021. PMID: 34578824 Free PMC article.

  • Ketogenic Diets and Chronic Disease: Weighing the Benefits Against the Risks.

    Crosby L, Davis B, Joshi S, Jardine M, Paul J, Neola M, Barnard ND. Crosby L, et al. Front Nutr. 2021 Jul 16;8:702802. doi: 10.3389/fnut.2021.702802. eCollection 2021. Front Nutr. 2021. PMID: 34336911 Free PMC article. Review.

  • The effect of high-fat versus high-carb diet on body composition in strength-trained males.

    Wrzosek M, Woźniak J, Włodarek D. Wrzosek M, et al. Food Sci Nutr. 2021 Mar 11;9(5):2541-2548. doi: 10.1002/fsn3.2204. eCollection 2021 May. Food Sci Nutr. 2021. PMID: 34026070 Free PMC article.

  • Ketogenic Diets Induced Glucose Intolerance and Lipid Accumulation in Mice with Alterations in Gut Microbiota and Metabolites.

    Li Y, Yang X, Zhang J, Jiang T, Zhang Z, Wang Z, Gong M, Zhao L, Zhang C. Li Y, et al. mBio. 2021 Mar 30;12(2):e03601-20. doi: 10.1128/mBio.03601-20. mBio. 2021. PMID: 33785628 Free PMC article.

LinkOut - more resources

  • Full Text Sources

    • Europe PubMed Central
    • PubMed Central

  • Medical

    • ClinicalTrials.gov

What Does Keto Diet Do to Cholesterol Levels

Source: https://pubmed.ncbi.nlm.nih.gov/19641727/